Current Grants
Hai Lin (PI) and Emilie Guidez (co-PI)
- NSF 2022: Adaptive multi-layer simulations of NarK transport protein
Scott Reed (PI) and Doris R. Kimbrough
- NIH 2020: Rocky Mountain summer research education experience
- ACS Petroleum Research Fund 2021: Computational investigation of thiolate-protected gold nanoclusters for syngas production
- NIH 2025: Development of near-infrared photothermal chemiluminescent gold nanoprobes by utilizing retro Diels-Alder reaction of trapped singlet oxygens
- Cancer League of Colorado 2025: Precision surgery in head and neck cancer with advanced chemiluminescent nanoprobes
- NIH 2024: Body heat activated, storable, near-infrared, self-illuminating nanoprobes for chemiluminescence imaging of cancer
- Wings of Hope 2025: Enhancing precision surgery in pancreatic cancer using advanced luminescent nanoprobes
- NSF 2024: Artificial intelligence-assisted integrative biomolecular NMR platform
- NIH 2023: Identifying genetic contributions to adverse drug reactions
- NIH 2024: Exploring the 5'-GUAC- sequence as an important RNA-motif
- NIH 2023: 8-Oxo-7,8-dihydroguanosine in aptamer development and its impact on RNA structure
NSF/CMTC: PI- “Developing the multilayer multiconfiguration time-dependent Hartree theory”
- NIH 2021: Variant-specific dynamics of amyloid-b fibrils
Past Grants (since 2009)
Jeff Knight (PI) and Hai Lin (co-PI)
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Research Corporation for Science Advancement, 2013: Hydrophobic and electrostatic driving forces for protein-membrane docking: A combined experimental and computational approach
Scott Reed (PI) and Liliya Vugmeyster
- NSF 2017: MRI: Acquisition of high-sensitivity, solids capable 400 MHz NMR for research and undergraduate training at the University of Colorado at Denver
- NSF 2018: M13 phage: a model system for complex control of multicomponent processes in biology
- NSF 2015: Sense codon reassignment: evaluating the plasticity of the E. coli genetic code
- Colorado Bioscience Association Bioscience Discovery Evaluation Grant Program (BDEGP) 2012: Biosensor platform development with protein assembly engineering and device integration
- Boettcher Foundation Webb-Waring Biomedical Investigator 2011: Transformative improvements in biomedical sensors through protein assembly engineering
- Bill and Melinda Gates Foundation Grand Challenges Explorations Grant 2010: Non-invasive phage particle-based sensors for active TB infection
- Vera Chem LLC 2020: Statistical mechanics with quantum potentials: Applications to protein-ligand binding affinities
- Department of Defense 2020: Cooperative agreement with United States Department of Defense, U.S. Air Force Academy appointment as Distinguished Visiting Professor
- NSF 2017: Robert E. Noyce Program, CU Denver Noyce Track 1
- NSF 2011: Robert E. Noyce Program, Promoting Undergraduate Licensure through Science Education (PULSE)
- Camille and Henry Dreyfus Foundation 2018: Chemistry of interfacial protein-membrane interactions central to insulin secretion
- NIH 2018: Administrative Diversity Supplement Award
- NIH 2017: Administrative Diversity Supplement Award
- Fulbright U.S. Scholar Program 2017: Using NMR spectroscopy to determine the structure of a unique calcium-inhibited C2 doma
- NIH 2016: Ca2+-independent and Ca2+-inhibited membrane binding by synaptotagmin-like proteins.
- NIH 2013: Molecular mechanisms of protein-membrane interactions driving insulin secretion.
- Cancer League of Colorado 2022: Body heat activated, storable, near-infrared, self-illuminating nanoprobes for in vivo optical imaging of cancer
- Wings of Hope 2019: Targeted luminescent nanoprobes for in vivo optical imaging of pancreatic cancer
- NIH 2018 (co-PI): Contact lens to remove zinc ions for corneal melting.
- Head and Neck Cancer 2018: Near-infrared chemiluminescent nanoparticles (CNPs) for in vivo optical imaging of head and neck cancer
- Research Foundation of Korea 2018: development of photothermal nanodiamond based on permeableness through blood brain barrier and brain targeting for glioma therapy
- Cancer League of Colorado 2017: storable, thermally activated, self-illuminating nanoparticles optical imaging of cancer
- American Cancer Society 2017: near-infrared self-illuminating nanoparticles for in vivo optical imaging of cancer
- NIH 2021 "Operation mechanism of CLCF fluoride/proton antiporter
- Research Corporation for Science Advancement 2018: Combining artificial neural networks and quantum chemistry for simulations of proton transfer through channels and transporters.
- NSF 2016: Adaptive QM/MM methods for proton transfer in complex environments.
- Camille & Henry Dreyfus Foundation 2014: Open-boundary QM/MM methods for multiscale modeling and simulations of chemical reactions in complex environments.
- National Renewal Energy Laboratory (Subcontract) 2013: Catalytic conversion of biomass
- NSF 2010: CAREER: Multiscale simulations of chloride transport proteins by combined quantum and classic mechanical approaches.
- NSF 2009 (Subcontract) Institute for Mathematics and its Applications: Mathematics and Chemistry.
- Research Corporation for Science Advancement 2011:
- NIH 2013: Interactions of C-reactive protein with highly curved lipid membranes
- NSF 2010: Collaborative research: A nanostructured model of the apoptotic cell surface
- NSF 2009: Collaborative: Spider fluorescence as a potential visual signal; IOS-0920768; PI: Scott Reed; 09/01/2009; $55,947
- NIH 2009: Interactions of C-reactive protein isoforms with oxidized lipid membranes
- NIH 2019: Spatial organization of epigenetic complexes and chromatin.
- NIH 2015: Molecular mechanisms of chromosomal segregation by epigenetic regulators.
- American Cancer Society 2014 (subaward): Polycomb group protein Cbx2 controls chromosome stability by coordinating with chromosome segregation proteins.
- NIH 2024: Exploring the 5'-GUAC- sequence as an important RNA-motif
- NIH 2023: 8-Oxo-7,8-dihydroguanosine in aptamer development and its impact on RNA structure.
- Camille and Henry Dreyfus Foundation 2021: Structure-function relationships of chemically modified RNA: The quest to retain students in chemistry.
- Organic Syntheses, Inc. 2020: Organic Syntheses Research Grant for Faculty at Principally Undergraduate Institutions: Diastereoselective formation of mono-, di-, tri-, and tetra-substituted cyclobutyl rings via photochemical approaches in the solid-state and in solution.
- NIH 2019: Design of apatmers of RNA containing 8-oxo-7, 8-dihydroguanosine: Function and selection of aptamers with novel properties.
- NSF 2020: Developing the multilayer multiconfiguration time-dependent Hartree theory.
- NSF 2014: Developing the multilayer multiconfiguration time-dependent Hartree theory.
- NSF 2010: Quantum dynamics study of ultrafast electron transfer reactions.
- NIH 2018: Dynamics of disordered regions of amyloid fibrils
- NIH 2014: Contributions of hydrophobic residues into thermodynamics and kinetics of amyloid.
- NSF 2011: RUI: Probing the free energy landscape of protein hydrophobic cores by solid-state NMR
- NIH 2011: Investigation of dynamics of headpiece proteins using NMR relaxation experiments