Bio-Organic Chemistry, Physical Organic Chemistry, Organic Synthesis
Postdoctoral Fellow, Johns Hopkins University
PhD. Organic Chemistry, University of California, Los Angeles
B.S. Chemistry, University of Utah
Dr. Resendiz began his academic career as an undergraduate student at the University of Utah working with Professor Peter J. Stang. While there, he worked on the design and synthesis of supramolecular metallacyclic architectures and studied their properties as sensors and storage devices. He ultimately received his PhD at the University of California, Los Angeles working under Professor Miguel A. Garcia-Garibay. Dr. Resendiz developed solvent free (solid-to-solid) reactions useful in the synthesis of complex natural products containing stereogenic quaternary centers as part of his Ph.D research. Prior to joining UC Denver, Dr. Resendiz completed a Postdoctoral position with Professor Marc M. Greenberg at Johns Hopkins University, where he studied the mechanisms that lead to RNA strand scission upon oxidative damage.
Dr. Resendiz is current involved in research that includes the interface of organic and biological chemistry. The goals are (1) to use photoactive short RNA libraries in the exploration of RNA-ligand interactions for applications in biosensing technologies i.e., finding good candidates for therapeutic purposes and (2) to explore the potential link between RNA oxidative damage and a variety of neurodegenerative and muscular diseases.
Photochemical Control of RNA Structure by Disrupting π-Stacking. Resendiz, M. J. E.; Schön, A.; Freire, E.; Greenberg, M. M. J. Am. Chem. Soc. 2012, 134, 12478-12481.
Direct Strand Scission in Double Stranded RNA via a C5-Pyrimidine Radical. Resendiz, M. J. E.; Pottiboyina, V.; Sevilla, M.; Greenberg, M. M. J. Am. Chem. Soc. 2012, 134, 3917-3924.
Product and Mechanistic Analysis of the Reactivity of a C6-Pyrimidine Radical in RNA. Jacobs, A. C.; Resendiz, M. J. E.; Greenberg, M. M. J. Am. Chem. Soc. 2011, 133, 5152-5159.
Direct Strand Scission from a Nucleobase Radical in RNA. Jacobs, A. C.; Resendiz, M. J. E.; Greenberg, M. M. J. Am. Chem. Soc. 2010, 132, 3668-3669. Selected for JACS Select on JACSβ #12, Chemical Mechanisms in Biochemical Reactions.
The Missing Link Between Molecular Triplets and Spin-Polarized Free Radicals: Room Temperature Triplet States of Nanocrystalline Radical Pairs. Lebedeva, N. V.; Tarasov, V. F.; Resendiz, M. J. E.; Garcia-Garibay, M. A.; White, R. C.; Forbes, M. D. E. J. Am. Chem. Soc. 2010, 132, 82-84. Highlighted in C & EN: Better View of Solid-State Reactions, Wilson, E. K.; C & EN: 2010, 88, 26.
Photochemical Generation and Reactivity of the 5,6-Dihydrouridin-6-yl Radical. Newman, C. A.; Resendiz, M. J. E.; Sczepanski, J. T.; Greenberg, M. M. J. Org. Chem. 2009, 74, 7007-7012.
Radical Reactions with Double Memory of Chirality (2MOC) for the Enantiospecific Synthesis of Adjacent Stereogenic Quaternary Centers in Solution: Cleavage and Bonding Faster than Radical Rotation. Resendiz, M. J. E.; Family, F.; Fuller, K.; Campos, L. M.; Khan, S. I.; Lebedeva, N. V.; Forbes, M. D. E.; Garcia-Garibay, M. A. J. Am. Chem. Soc. 2009, 131, 8425-8433. Highlighted in nature.com blogs: The Way We Were: Double Memory of Chirality, posted on Saturday, June 27th, 2009.
Diastereoselective synthesis and spin-dependent photodecarbonylation of di(3-phenyl-2-pyrrolidinon-3-yl)ketones: synthesis of nonadjacent and adjacent stereogenic quaternary centers. Resendiz, M. J. E.; Natarajan, A.; Garcia-Garibay, M. A. Chem. Commun. 2008, 193-195.
Unexpected Solid-State Photochemistry of an α-Thiophenyl-α‘-Thiophenyl-S,S-dioxo-Substituted Ketone. Resendiz, M. J. E.; Taing, J.; Khan, S. I.; Garcia-Garibay, M. A. J. Org. Chem. 2008, 73, 638-643.
Photodecarbonylation of 1,3-Dithiophenyl Propanone: Using Nanocrystals to Overcome the Filtering Effect of Highly Absorbing Trace Impurities. Resendiz, M. J. E.; Taing, J.; Garcia-Garibay, M. A.; Org. Lett. 2007, 9, 4351.
Large-Scale Photochemical Reactions of Nanocrystalline Suspensions: A Promising Green Chemistry Method. Veerman, M.; Resendiz, M. J. E.; Garcia-Garibay, M. A. Org. Lett. 2006, 8, 2615.
Hammett Analysis of Photodecarbonylation in Crystalline 1,3-Diarylacetones. Resendiz, M. J. E.; Garcia-Garibay, M. A., Org. Lett. 2005, 7, 371-374.
Self-Assembly of Flexible Supramolecular Metallacyclic Ensembles: Structures and Adsorption Properties of Their Nanoporous Crystalline Frameworks. Chatterjee, B.; Noveron, J. C.; Resendiz, M. J. E.; Liu, J.; Yamamoto, T.; Parker, D.; Cinke, M.; Nguyen, C. V.; Arif, A. M.; Stang, P. J. J. Am. Chem. Soc. 2004, 126, 10645-10656.
A Self-Assembled Supramolecular Optical Sensor for Ni(II), Cd(II), and Cr(III). Resendiz, M. J. E.; Noveron, J. C.; Disteldorf, H.; Fischer, S.; Stang, P. J. Org Lett. 2004, 6, 651-653.