Prof.Sehoon Park
Abstract
In the first part of this seminar, we present our recent developments in transition metal (Rh, Co)-
catalyzed (asymmetric) double hydroboration of quinolines and pyridines.1-4 Particular emphasis is placed
on highly challenging, unprecedented ligand-controlled regiodivergent double hydroboration of pyridines.
As a catalytic platform, this methodology enables the selective synthesis of two pairs of
multifunctionalized piperidine isomers. The origin of this regiodivergent ligand effect is elucidated
through combined experimental and computational mechanistic studies. The second part of the
presentation describes the extension of this substrate scope from pyridines to (a)cyclic conjugated
systems—including enals, enones, and enimines—by employing sustainable and simple Co-based
catalytic systems.5 This straightforward catalytic approach establishes the first example of metal-catalyzed
(regiodivergent) (asymmetric) double hydroelementation (E ≠ H) of pyridines, as well as the first
(chemodivergent) (asymmetric) double hydroboration of enones and enimines
When: September 25, 2026
Where: North Classroom 1535
Time: 11:00 am - 12:00pm