C. Andrew Frank, Ph.D.
Abstract
Neurons require large amounts of energy to transmit signals and maintain communication with their targets. A fundamental question is how different cells meet these energetic demands while preserving reliable function. Our laboratory studies this problem using the fruit fly Drosophila melanogaster, a powerful model for understanding the basic principles of nervous system function. We examine how two distinct classes of motor neurons respond when synaptic signaling is weakened. Although both neuron types can compensate and restore communication, they do so through different biological mechanisms. Our results suggest that neuron identity influences not only the genes used to support synaptic stability but also the metabolic pathways that provide the energy required for that response. One neuron type appears to rely more strongly on mitochondrial energy production, whereas the other depends more heavily on glycolysis. These findings highlight how cellular metabolism and neuronal identity interact to support robust communication in the nervous system.
When: September 4, 2026
Where: North Classroom 1535
Time: 11:00 am - 12:00pm