Welcome to the Department of Integrative Biology, with research-based programs that prepare our students to become critical problem solvers. We recognize science not as a collection of facts, but as a process designed to help students make informed decisions about the nature of evidence. Our faculty are funded in cutting-edge research in a broad range of biological disciplines and our community of students actively engage in research learning environments that encourage publication and job training.
Our department offers BS, MS, and PhD degree programs, with opportunities for students to specialize in a range of fields. In addition, we offer two undergraduate certificates in Biotechnology and in Environmental Stewardship of Indigenous Lands (ESIL).
Faculty Position Available
The Department of Integrative Biology is hiring an Assistant Professor in Physiology Systems Biology. Click here for details.
Department of Integrative Biology
2019 Spring Seminar Series
Dr. Suzanne McDermott
Research Scientist IV
Seattle Children’s Research Institute
When: Friday, Feb. 22nd
Where: SI 2001 at Noon
’High-resolution mapping of protein motifs and interactions essential for RNA editing’
RNA editing creates functional mitochondrial mRNAs in the protozoan parasites Trypanosoma brucei, T. cruzi, and Leishmania species. Its regulation during the trypanosome life-cycle is essential for the adaptation of parasites to the different environments they encounter in their mammalian hosts and insect vectors. The enzymes that catalyze RNA editing are found in large multiprotein complexes termed editosomes, that also contain several proteins lacking homology to known catalytic or other protein domains. I will describe the results of high-resolution structure-function analyses, including cross-linking mass spectrometry, integrative structural modeling, and deep mutational scanning, that I have used to interrogate the unknown protein motifs and interactions within editosomes. This work has generated the first global map of protein interactions within editosomes, and provided the first insights into regulation of editing during the trypanosome life-cycle, which will aid therapeutic development against these deadly pathogens.
Everyone is welcome to the seminar. If you would like to meet with the speaker, please email Dr. Chris Miller