Kaia Mattioli

Kaia is an incoming Assistant Professor in the Department of Integrative Biology at the University of Colorado Denver. She is interdisciplinary by nature, with expertise in both computational and experimental biology. Kaia has a long-standing goal of making science and academia more inclusive environments, and as such aims for her lab to be a welcoming and supportive place to train the next generation of scientists. mattioli-lab.org 

She earned her PhD at Harvard University in the Biological and Biomedical Sciences Program, where she used high-throughput methods to study the function of long non-coding RNAs with John Rinn and Marta Melé. She then joined Martha Bulyk’s lab across the Charles River at Brigham and Women’s Hospital and Harvard Medical School, where she studied alternative isoforms of transcription factors.

Recent selected publications

2025 -  Mattioli K, Bulyk ML. Beyond the gene: Decoding alternative isoforms. Trends in Genetics.

2025 - Lambourne L*, Mattioli K*†, Santoso C*, Sheynkman G, Inukai S, Kaundal B, Berenson A, Spirohn-Fitzgerald K, Bhattacharjee A, Rothman E, Shrestha S, Laval F, Carroll BS, Plassmeyer SP, Emenecker RJ, Yang Z, Bisht D, Sewell JA, Li G, Prasad A, Phanor S, Lane R, Moyer DC, Hunt T, Balcha D, Gebbia M, Twizere J, Hao T, Holehouse AS, Frankish A, Riback JA, Salomonis N, Calderwood MA, Hill DE, Sahni N†, Vidal M†, Bulyk ML†, Fuxman Bass JI†. Widespread variation in molecular interactions and regulatory properties among transcription factor isoforms. Molecular Cell.

2024 - Schade AE, Perurena N, Yang Y, Rodriguez CL, Krishnan A, Gardner A, Loi P, Xu Y, Nguyen VTM, Mastellone GM, Pilla NF, Watanabe M, Ota K, Davis RA, Mattioli K, Xiang D, Zoeller JJ, Lin J-R, Morganti S, Garrido-Castro AC, Tolaney SM, Li Z, Barbie DA, Sorger PK, Helin K, Santagata S, Knott SRV, Cichowski K. AKT and EZH2 Inhibitors kill TNBCs by hijacking mechanisms of involution. Nature

.
-- * = co-first author; † = co-corresponding author
-- Full publication list on my Google Scholar: https://scholar.google.com/citations?hl=en&user=57uMDxwAAAAJ