Congratulations Gabrielle Brandt!
Ph.D. Degree Candidate
Dr. Chris Phiel's Lab
CU Denver Department of Integrative Biology
When: Thursday, July 11th, 2024, 10:00am
Where: Science Building, Room 4127
Regulatory mechanisms underlying mESC pluripotency and m6A methylation dynamics: AMF and AMFR
Pluripotent embryonic stem cells (ESCs) hold immense promise in regenerative medicine, yet the precise regulatory mechanisms governing the pluripotent state remain elusive. This defense presentation examines the interplay between cell signaling and epigenetics in regulating ESC pluripotency. My research highlights the role of autocrine motility factor (AMF) and its receptor (AMFR) in ESC pluripotency, revealing new regulatory mechanisms. We found that AMFR's influence on an epigenetic methytransferase complex may be crucial, offering fresh insights into stem cell biology.