Congratulations Jeffrey on your successful thesis defense!

CU Denver Department of Integrative Biology M.S. Thesis Defense

Jeffrey Mayfield
M.S. Degree Candidate, Dr. Amanda Charlesworth’s Lab
CU Denver Department of Integrative Biology

WHEN: July 22, 2022
WHERE: Room SI 2001  at 11:00am

"Protein and RNA Interactions of Zygote Arrest Proteins 1 and 2 in Xenopus Laevis"

Zygote arrest (Zar) proteins have been shown to have critical roles in early development. While studies have shown that Zar1 and Zar2 bind to maternal mRNAs in the oocyte and lead to repression, and that this repression is relieved once the oocyte matures, the mechanism and RNA targets of this repression are still unknown. My Thesis is focused on determining the protein and RNA interactions of endogenous Zar proteins to generate a more complete picture of how these proteins cause repression as well as the target of this repression to better understand the role of Zar proteins during development.