Published: May 1, 2020

Who: Dr. Isabel R. Schlaepfer.
Title: CPT1A: An old Actor in Metabolism Auditioning for New Cancer Roles.
When: Friday, May 8, 2020 at Noon.
Where: Seminars are being presented at noon
via Zoom:
https://ucdenver.zoom.us/j/434850347
Meeting ID: 434 850 347.

Diagram for seminar

Dr. Isabel R. Schlaepfer
University of Colorado School of Medicine
Division of Medical Oncology
Genitourinary Cancer Program

Targeting metabolic changes in cancer cells may enable the development of novel therapies or the enhancement of existing ones. My lab studies how cancer cells use lipid to their benefit, with focus on how they burn it to resist drug treatments and continue growing. Carnitine palmitoyl transferase 1A (CPT1A) is a liver enzyme that shuttles long-chain lipids into the mitochondria, controlling the rate of fat oxidation. Unexpectedly, this liver enzyme is very abundant in common cancers like breast and prostate cancers, making it a good target for therapeutic interventions. In this talk, I will discuss the role of CPT1A in normal physiology and disease, with focus on prostate cancer. The first line of therapy for prostate cancer is blocking the androgen hormones that fuel the cancer growth. However, this approach is not very effective, and patients progress to an aggressive form of the disease that is currently incurable. We have found that in these aggressive tumors, CPT1A and the androgen receptor have a peculiar relationship. Understanding how this relationship works at the molecular level will help us identify and design new therapies to halt cancer progression.

Everyone is welcome to the seminar. If you would like to meet with the speaker, please email Dr. Brian Buma at brian.buma@ucdenver.edu

Zoom Link:

https://ucdenver.zoom.us/j/434850347  Meeting ID: 434 850 347. 

One tap mobile

+16699006833,,434850347# US (San Jose)

+13462487799,,434850347# US (Houston)

Dial by your location

        +1 669 900 6833 US (San Jose)

        +1 346 248 7799 US (Houston)

        +1 301 715 8592 US

        +1 312 626 6799 US (Chicago)

        +1 646 876 9923 US (New York)

        +1 253 215 8782 US

Meeting ID: 434 850 347

Find your local number: https://ucdenver.zoom.us/u/ad4k2VvU7

Join by SIP

434850347@zoomcrc.com

Join by H.323

162.255.37.11 (US West)

162.255.36.11 (US East)

221.122.88.195 (China)

115.114.131.7 (India Mumbai)

115.114.115.7 (India Hyderabad)

213.19.144.110 (EMEA)

103.122.166.55 (Australia)

209.9.211.110 (Hong Kong)

64.211.144.160 (Brazil)

69.174.57.160 (Canada)

207.226.132.110 (Japan)

Meeting ID: 434 850 347