Congratulations to Dr. Yaning Liu for being coPI on NIH Grant Number 1R01AG087163-01A1 entitled "Quantifying the Integrity of Sleep-Dependent Memory Processing in Pathological Aging and Alzheimer's Disease: Toward Inexpensive Electroencephalographic Wearable Applications". The award runs from 2024 to 2029, totals $3,691,683.
Abstract: Simple single-channel electroencephalography (EEG) sleep recordings contain information about memory circuits that may form the basis of a digital biomarker for monitoring brain health and for the detection of early Alzheimer’s disease changes. Our team has pioneered novel methods to measure sleep’s memory circuits from sleep EEG, and we have observed striking changes in these circuits with aging and in the early stages of Alzheimer’s disease. Here, we propose to incorporate our signal processing methods into cutting-edge machine learning models with the goal to develop predictive models that can serve as a powerful digital biomarker to detect pathological aging, predict cognitive decline, and detect early stages of Alzheimer’s disease.