Publications

Nakamura, M., Liu, T., Husain, S., Zhai, P., Warren, J.S., Hsu, C.-P., Matsuda, T., Phiel, C.J., Cox, J., Tian, B., Li, H., and Sadoshima, J. (2019) Glycogen Synthase Kinase-3α Promotes Fatty Acid Uptake and Lipotoxic Cardiomyopathy, Cell Metabolism, 29:1-16, doi.org/10.1016/j.cmet2019.01.005, PMID: 30745182.

Faulds, K.J., Egelston, J.N., Sedivy, L.J., Mitchell, M.K., Garimella, S., Kozlowski, H., D’Alessandro, A., Hansen, K.C., Balsbaugh, J.L., and Phiel, C.J. (2018) Glycogen synthase kinase-3 (Gsk-3) activity regulates mRNA methylation in mouse embryonic stem cells, Journal of Biological Chemistry, 293:10731-10743, doi:10.1074/jbc.RA117.001298, PMID: 29777057. **Also featured in special virtual issue from JBC on Pluripotency Regulation and Differentiation - http://www.jbc.org/site/vi/pluripotency/

Tatavosian, R., Huynh, T.N., Duc, H.N., Fang, D., Schmitt, B., Grimm, J.B., Phiel, C.J., Lavis, L.D., Yao, T., Zhang, Z., Wang, H., and Ren, X. (2018) Live-Cell Single-Molecule Dynamics of PcG Proteins Imposed by the DIPG H3.3K27M Mutation, Nature Communications, 9:2080, DOI:10.1038/s41467-018-04455-7, PMID: 29802243.

Gonzalez Malagon, S.G., Lopez Munoz, A.M., Doro, D., Bolger, T.G., Poon, E., Tucker, E.R., Al-Lami, H.A., Krause, M., Phiel, C.J., Chesler, L., and Liu, K.J. (2018) Glycogen Synthase Kinase-3 Controls Migration of the Cranial Neural Crest Lineage in Mouse and Xenopus, Nature Communications, 9:1126, DOI:10.1038/s41467-018-03512-5, PMID: 29555900.

Bhattacharjee, R. Goswami, S., Dey, S., Gangoda, M., Brothag, C., Eisa, A., Woodgett, J., Phiel, C.J., Kline, D., and Vijayaraghavan, S. (2018) Isoform-Specific Requirement for GSK-3α in Sperm for Male Fertility, Biology of Reproduction, 99:384-394, DOI:10.1093/biolre/ioy020, PMID: 29385396.

Fowler, J.J., Braley, K.L., Farero, R.D., Russell, E., Phiel, C.J., Kisley, M.A., and Albeck, D.S. (2018) The late positive potential and subjective arousal ratings evoked by negative images vary as a function of oxytocin receptor genotype SNP rs53576, NeuroReport, 29(14):1145-1150, DOI: 10.1097/WNR.0000000000001085, PMID: 29958244.

Meredith G, D’Ippolito A, Zeidner LC, Hostetter L, Faulds K, Arnold TH, Popkie AP, Doble BW, Marnellos G, Adams C, Wang Y, and Phiel CJ (2015) Glycogen Synthase Kinase-3 (Gsk-3) Plays a Fundamental Role In Maintaining DNA Methylation At Imprinted Loci In Mouse Embryonic Stem Cells, Molecular Biology of the Cell 26(11): 2139-2150, PMID: 25833708.

Battacherjee R, Dudki T, Goswami S, Popkie A, Phiel CJ, Kline D, and Vijayaraghavan S (2015) Targeted disruption of GSK-3α affects sperm motility resulting in male infertility, Biology of Reproduction 92:1-12, PMID: 25568307.

Bartman CM, Egelston J, Ren X, Das R, and Phiel CJ (2015) A Simple and Efficient Method for Transfecting Mouse Embryonic Stem Cells Using Polyethylenimine, Experimental Cell Research 330: 178-185, PMID: 25102378.

Zhen CY, Duc, HN, Kokotovic M, Phiel CJ, and Ren X (2014) Immobilization of PRC1 Complex at Mitotic Chromosomes by Cbx2 in a PRC2-Independent Mechanism, Molecular Biology of the Cell 25(23):3726-3739, PMID: 25232004.

Bartman CM, Egelston J, Zeidner LC, D’Ippolito, A, Kattula S, Doble BW, and Phiel CJ (2014) Gene expression profiling in mouse embryonic stem cells reveals glycogen synthase kinase-3-dependent targets of phosphatidylinositol 3-kinase and Wnt/β-catenin signaling pathways, Frontiers in Endocrinology 5:133, PMID: 25165462.

Phiel CJ, Wilson CA, Lee VM-Y and Klein PS (2011) Reply to GSK-3α/β kinases and amyloid production in vivo, Nature 480:E6, PMID: 22158251.

Zeidner LC, Buescher JL, and Phiel CJ (2011) A Novel Interaction Between Glycogen Synthase Kinase-3α (GSK-3α) and the Scaffold Protein Receptor for Activated C-Kinase 1 (RACK1) Regulates the Circadian Clock, International Journal of Biochemistry and Molecular Biology 2(4):318-327, PMID: 22187666.

Fleming JL, Phiel CJ, and Toland AE (2011) The Role for Oxidative Stress in Aberrant DNA Methylation in Alzheimer’s Disease, Current Alzheimer Research 9(9):1077-1096, PMID: 21605062.

Popkie AP, Zeidner LC, Albrecht AM, D’Ippolito A, Eckardt S, Newsom DE, Groden J, Doble BW, Aronow B, McLaughlin KJ, White P, Phiel CJ (2010) Phosphatidylinositol 3-Kinase (PI3K) Signaling via Glycogen Synthase Kinase-3 (Gsk-3) Regulates DNA Methylation of Imprinted Loci., Journal of Biological Chemistry 285(53):41337-47, PMID: 21047779.

He F, Popkie AP, Xiong W, Li L, Wang Y, Phiel CJ, Chen Y. (2010) Gsk3β is required in the epithelium for palatal elevation in mice., Developmental Dynamics 239(12):3235-46, PMID: 20981831.

Yang J, Phiel CJ. (2010) Functions of B56-containing PP2As in major developmental and cancer signaling pathways., Life Sciences 87(23-26):659-66. Review, PMID: 20934435.

Buescher JL and Phiel CJ (2010) A non-catalytic domain of glycogen synthase kinase-3 (GSK-3) is essential for activity,Journal of Biological Chemistry 285:7957-7963, PMID: 20080974.

Rorick AM, Mei W, Liette NL, Phiel CJ, El-Hodiri HM, Yang J. (2007) PP2A:B56epsilon is required for eye induction and eye field separation., Developmental Biology 302(2):477-93, PMID: 17074314.

Checler F, Alves da Costa C, Ayral E, Andrau D, Dumanchin C, Farzan M, Hernandez JF, Martinez J, Lefranc-Jullien S, Marambaud P, Pasini A, Petit A, Phiel CJ, Robert P, St. George-Hyslop P and Wilk S (2005) JLK inhibitors: Isocoumarin compounds as putative probes to selectively target the γ-secretase pathway, Current Alzheimer Research 2:327-334, PMID: 15974898.

Phiel CJ, Wilson CA, Lee VM-Y and Klein PS (2003) GSK-3α Regulates Production of Alzheimer’s Disease Amyloid-β Peptides, Nature 423:435-439, PMID: 12761548.

Zhang F, Phiel CJ, Spece L, Gurvich N and Klein PS (2003) Inhibitory phosphorylation of Glycogen Synthase Kinase-3 (GSK-3) in Response to Lithium: Evidence for Autoregulation of GSK-3, Journal of Biological Chemistry 278:33067-33077, PMID: 12796505.

Checler F, Pasini A, Alves da Costa C, Ayral E, Hernandez JF, Dumanchin-Njock C, Phiel CJ, Marambaud P, Wilk S, Farzan M, Boisbrun M, Fulcrand P, Martinez J, Andrau D, and Petit A (2003) JLK isocoumarin inhibitors: Selective γ-secretase inhibitors that do not interfere with Notch pathway in vitro or in vivo, Journal of Neuroscience Research 74:370-377, PMID: 14598313.

Gabetta V, Trzyna WT, Phiel CJ and McHugh KM (2003) Vesicle-Associated Protein-A is Differentially Expressed During Intestinal Smooth Muscle Cell Differentiation, Developmental Dynamics 228:11-20, PMID: 12950075.

Phiel CJ, Zhang F, Huang EY, Guenther MG, Lazar MA and Klein PS (2001) Histone Deacetylase is a Direct Target of Valproic Acid, a Potent Anticonvulsant, Mood Stabilizer, and Teratogen, Journal of Biological Chemistry 276:36734-36741, PMID: 11473107.

Phiel CJ and Klein PS (2001) Molecular Targets of Lithium Action, Annual Reviews in Pharmacology and Toxicology 41:789-813, PMID: 11264477.

Phiel CJ, Gabbeta V, Parsons LM, Rothblat D, Harvey RP and McHugh KM (2001) Differential binding of an SRF/NK-2 transcription factor complex in normal versus neoplatic smooth muscle tissues, Journal of Biological Chemistry 276:34637-34650, PMID: 11457859.

Brittingham JW*, Phiel CJ*, Trzyna WT*, Gabbeta V, and McHugh KM (1998) Identification of Distinct Molecular Phenotypes in Cultured Gastrointestinal Smooth Muscle Cells, Gastroenterology 115:605-617, PMID: 9721158 (*Authors contributed equally).