We are working to create tools that facilitate searching the genome for variants that can elucidate previously unexplained adverse drug reactions (ADRs). One goal is to create an online tool that allows users to identify specific ADRs and the drugs that cause those ADRs, and then to generate lists of pharmaceuticals, their three dimensional structures, and their likely metabolism products. A second goal is to create an online tool that generates a list of candidate genetic variants that have the potential to explain specific ADRs. Together these tools can be used by researchers to prioritize drug protein interactions for further in silico or in vitro studies. These tools will facilitate rapid testing of hypotheses about pharmacogenomics causes of harmful drug side effects.
University of Colorado Denver