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Cafe Scientifique2

March 25
6:30 PM
Brooklyn’s (901 Auraria Parkway)

"What genes make us human?" by Dr. James M. Sikela, Professor of Biochemistry and Molecular Genetics, University of Colorado School of Medicine

Given the unprecedented tools that are now available for rapidly comparing genomes, the identification and study of genomic changes that are unique to humans has accelerated, and it can be said that we are now entering a golden age of human evolutionary genomics. Dr. Sikela will provide an overview of these efforts, highlighting important recent discoveries. He will also describe his finding that genes for “DUF1220 protein domains” are dramatically changed in humans and have recently been implicated in changes in brain size. Finally he will describe work that indicates that some of the most evolutionary advantageous changes in the human genome have come at a severe price in terms of also promoting disease. Is this always the case with “progress”?

EVERYONE IS WELCOME. The discussion starts at 6:30 in the upstairs lounge area. Come before 6 PM to leave yourself time to get something to eat.  We end around 8 PM. There’s no charge. Brooklyn’s is generously providing the facility; we buy our own food & drinks. It is first come, first seated, and seating is limited so that everyone can take part in the discussion. Brooklyn’s is next to the Pepsi Center, across Auraria Parkway from the Auraria Campus. Parking is free in Pepsi Center lot around the circle, SW of Brooklyn’s.

We welcome your input, including ideas for speakers and topics. Bring them with you to the next Café2, or e-mail them and any questions to Essential information about Café Sci2, speaker, and topic is on our Web site at:

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Tracy Kohm 303.556.6663