Figure 2. Examples of aptamers are depicted: The RNA-based aptamer (A) recognizes theophylline (JACS, 2005 Mecozzi et al.) to form a hairpin, whereas the pre-Q1 class I riboswitch (C) recognizes its target and gives rise to pseudoknot formation (JACS, 2012, Resendiz et al.). The DNA-based split aptamer (B) recognizes cocaine and brings the two strands together (JACS, 2011, Heemstra et al.)
We are interested in the design and synthesis of RNA-based structures that can be used as sensors for small molecules in order to explore their potential for applications in biologically relevant systems i.e., finding good candidates for therapeutic purposes.
News & Updates
Publications of interest:
DNA: Computational and spectroscopic characterization of Spiroiminodihydantoin
The absolute configuration of this important DNA base lesion is described by Burrows et al.
Pesticides and Parkinson's relation described in Science.
Paraquat, a common pesticide, increases oxidative stress and is associated to PD.
RNA recognition by Freisinger et al.
A di-iron(II) supramolecular cylinder is able to recognize an RNA three way junction.
A Chemist's Perspective
Check out this recent article from Angewandte Chemie: "How a Chemist Looks at RNA"; by Nobel Laureate Thomas R. Cech.
Check back for more interesting articles, news, and updates from the Resendiz research group.