Figure 2. Examples of aptamers are depicted: The RNA-based aptamer (A) recognizes theophylline (JACS, 2005 Mecozzi et al.) to form a hairpin, whereas the pre-Q1 class I riboswitch (C) recognizes its target and gives rise to pseudoknot formation (JACS, 2012, Resendiz et al.). The DNA-based split aptamer (B) recognizes cocaine and brings the two strands together (JACS, 2011, Heemstra et al.)
We are interested in the design and synthesis of RNA-based structures that can be used as sensors for small molecules in order to explore their potential for applications in biologically relevant systems i.e., finding good candidates for therapeutic purposes.
News & Updates
Marti Barrett Scholarship:
2014/2015 Barrett Scholarship recipient goes to Kristina Bueter.
Kudos to Katie!
Oxo-A & RNA - Structural Changes and Stability: Check the OpenAccess article here!
Synthesis, circular dichroism & thermodynamic parameters on hairpins, hetero- and homo-duplexes of RNA.
Congrats to Ana and Yu!
On their LA trip, Tewoderos Ayele and Ana M. Chauca-Diaz presented posters on their progress.
Tewoderos won best poster award, Congrats!
Beatrice A. Guillermo presented her research progress in San Antonio.
Upcoming in 2015
Look for us at ACS Spring meeting in Denver!
The role of nucleobase interactions in RNA structure and dynamics (Bottaro et al.): Check this article here!
The separation between the 5'-3' ends in long RNA molecules is short and nearly constant (Leija-Martinez et al.): Check this article here!
Synthesis, biophysical prop., and biological activity of second generation antisense oligonucleotides containing phosphorothioate linkages (Wan et al.): Check this article here!
Check back for more interesting articles, news, and updates from the Resendiz research group.