Charlesworth, Knight and students publish on zygote arrest genes
Amanda Charlesworth, assistant professor of integrative biology, and Jefferson Knight, assistant professor in chemistry, had a paper published in the latest Biochimica et Biophysica Acta: 1829: 1034-1046 (Zar1 represses translation in Xenopus oocytes and binds to the TCS in maternal mRNAs with different characteristics than Zar2) . Charlesworth and her team found that all the Zygote arrest genes in the databases fell into only two evolutionarily conserved genes. They also showed that two zygote arrest genes have similar functional mechanisms, but with specific differences. These functional differences could be partially attributed to the evolutionarily conserved differences between the two genes. These studies were co-authored with CU Denver undergraduates Terry Khat, Kevin Silva and Michael Ferreyros, and graduate students Cassandra Kotter and Jonanthan Cook.